(R)-Verapamil hydrochloride |
| Catalog No.GC60408 |
(R)-베라파밀 염산염((R)-(+)-베라파밀 염산염)은 P-당단백질 억제제입니다. (R)-Verapamil 염산염은 MRP1 매개 수송을 차단하여 MRP1을 과발현하는 세포가 항암제에 화학 민감화되도록 합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 38176-02-2
Sample solution is provided at 25 µL, 10mM.
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(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs[1][2].
[1]. Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92. [2]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.
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