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(Rac)-IDO1-IN-5

Catalog No.GC38876

(Rac)-IDO1-IN-5(실시예 1)는 IDO1-IN-5의 라세미체이다. IDO1-IN-5는 Indoleamine 2,3-Dioxygenase 1(IDO1) 활성의 강력하고 선택적인 뇌 침투 억제제로 성숙한 헴 결합 IDO1보다는 헴이 결핍된 apo-IDO1에 결합합니다.

Products are for research use only. Not for human use. We do not sell to patients.

(Rac)-IDO1-IN-5 Chemical Structure

Cas No.: 2166616-74-4

Size 가격 재고 수량
5mg
US$167.00
재고 있음
10mg
US$278.00
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25mg
US$464.00
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50mg
US$742.00
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100mg
US$1,159.00
재고 있음
200mg Please Inquire Please Inquire
500mg Please Inquire Please Inquire

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고객 리뷰

Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).

Chemical Properties

Cas No. 2166616-74-4 SDF
Canonical SMILES O=C(NC(C1=CC2=C(N(C(C3CCOCC3)=O)CC2)C=C1)C)C4=CC=C(F)C=C4
Formula C23H25FN2O3 M.Wt 396.45
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6119 mL 25.2239 mL
5 mM 0.5045 mL 2.5224 mL 5.0448 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for (Rac)-IDO1-IN-5

Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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