>> Signaling Pathways >> Apoptosis >> Bcl-xL

Bcl-xL

BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.

Products for  Bcl-xL

  1. Cat.No. 상품명 정보
  2. GC17512 A-1155463 A-1155463은 Molt-4 세포에서 EC50이 70nM인 매우 강력하고 선택적인 BCL-XL 억제제입니다. A-1155463  Chemical Structure
  3. GC17513 A-1331852 A-1331852는 Ki가 10pM 미만인 경구용 BCL-XL 선택적 억제제입니다. A-1331852  Chemical Structure
  4. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737  Chemical Structure
  5. GC12139 Gambogic Acid A xanthonoid with anticancer activity Gambogic Acid  Chemical Structure
  6. GC11510 HA14-1 A Bcl-2 inhibitor HA14-1  Chemical Structure
  7. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins TW-37  Chemical Structure
  8. GC11921 WEHI-539 A selective Bcl-xL inhibitor WEHI-539  Chemical Structure
  9. GC13317 WEHI-539 hydrochloride WEHI-539 염산염은 IC50이 1.1nM인 Bcl-XL의 선택적 억제제입니다. WEHI-539 hydrochloride  Chemical Structure

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