DNA Intercalating Agents

Cat.No. 상품명 정보

GC48840 9-Methoxyellipticine

Methoxy-9-ellipticine, NSC 69187

An alkaloid with anticancer activity 9-Methoxyellipticine Chemical Structure

GC49804 Acridine

2,3,5,6-Dibenzopyridine, 10-Azaanthracene, Dibenzopyridine, NSC 3408

An azaarene Acridine Chemical Structure

GC42912 Becatecarin

BMS 181176, BMY 27557, NSC 655649, XL 119

베카테카린은 항종양 효과가 있는 레베카마이신 유사체입니다. 베카테카린은 DNA에 삽입되어 토포이소머라제 I/II의 촉매 활성을 억제합니다. Becatecarin Chemical Structure

GC43565 Doxorubicinol (hydrochloride)

13-Dihydroadriamycin hydrochloride

Doxorubicinol is the major metabolite of doxorubicin, an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. Doxorubicinol (hydrochloride) Chemical Structure

Doxorubicinol (hydrochloride) Chemical Structure

GC45998 Mitoxantrone-d8 Mitoxantrone-d8(mitozantrone-d8)은 Mitoxantrone이라고 표시된 중수소입니다. 미톡산트론은 토포이소머라제 II 억제제이며 또한 8.5μM의 IC50으로 단백질 키나제 C(PKC) 활성을 억제합니다. Mitoxantrone-d8 Chemical Structure

GC44438 Nogalamycin

NSC 70845, U 15167

CCG-273220은 220nM의 IC50 값을 갖는 G 단백질 결합 수용체(GPCR) 키나제 5(GRK5)의 공유 억제제입니다. CCG-273220은 GRK5 서브패밀리 특이적 잔기인 Cys474를 공유 핸들로 결합하여 GRK2(IC50=350μM)보다 GRK5에 대해 고도로 선택적입니다. Nogalamycin Chemical Structure

GC40859 Steffimycin B

NSC 204855, U 40615

Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. Steffimycin B Chemical Structure

GC48165 Thiocoraline

PM 93135

A depsipeptide and DNA bis-intercalator with antibacterial and anticancer activities Thiocoraline Chemical Structure

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