Search Site
  • 0
    장바구니

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

홈 >> Signaling Pathways >> Chromatin/Epigenetics >> Protein Ser/Thr Phosphatases

Protein Ser/Thr Phosphatases

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for  Protein Ser/Thr Phosphatases

  1. Cat.No. 상품명 정보
  2. GC17344 Alexidine dihydrochloride An alkyl bis(biguanide) antiseptic Alexidine dihydrochloride Chemical Structure
  3. GC15974 bpV(HOpic) (potassium salt, technical grade)

    Bisperoxovanadium(HOpic)

     bpV(HOpic)(칼륨 염, 기술 등급)는 IC50이 14nM인 강력하고 선택적인 PTEN 억제제입니다. bpV(HOpic) (potassium salt, technical grade) Chemical Structure
  4. GC17011 C2 Ceramide

    C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine

     A cell-permeable analog of naturally occurring ceramides C2 Ceramide Chemical Structure
  5. GC12082 Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor Cantharidic Acid (sodium salt) Chemical Structure
  6. GC12891 CCT007093 CCT007093은 효과적인 단백질 포스파타제 1D(PPM1D Wip1) 억제제입니다. Wip1 억제는 mTORC1 경로를 활성화하고 간절제술 후 간세포 증식을 향상시킬 수 있습니다. CCT007093 Chemical Structure
  7. GC15718 CID 2011756 An inhibitor of protein kinase D CID 2011756 Chemical Structure
  8. GC14024 DL-AP3 A metabotropic glutamate receptor antagonist DL-AP3 Chemical Structure
  9. GC14395 Fostriecin sodium salt A potent inhibitor of protein phosphatases 2A and 4 Fostriecin sodium salt Chemical Structure
  10. GC16117 INCA-6

    Triptycene-1,4-quinone

     A cell-permeant inhibitor of NFAT signaling INCA-6 Chemical Structure
  11. GC12189 LB-100 protein phosphatase 2A(PP2A)inhibitor LB-100 Chemical Structure
  12. GC17676 Nafamostat

    넓은 스펙트럼의 세린 프로테아제 억제제, 칼리크레인 억제제

     Nafamostat Chemical Structure
  13. GC16290 Nafamostat hydrochloride 합성 세린 프로테아제 억제제인 Nafamostat 염산염은 항응고제입니다. Nafamostat hydrochloride Chemical Structure
  14. GC14875 NSC 663284

    Cdc25 Phosphatase Inhibitor II, DA30031, SPS8I1

     NSC 663284(DA-3003-1)는 강력하고 세포 투과성이며 비가역적인 Cdc25 이중 특이성 포스파타제 억제제이며 Cdc25B2에 대한 IC50이 0.21μM입니다. NSC 663284는 각각 Ki 값이 29, 95 및 89nM인 Cdc25A, Cdc25B(2) 및 Cdc25C에 대해 혼합된 경쟁 동역학을 나타냅니다. NSC 663284는 촉매 SET 도메인(Kd 370nM)과의 직접적인 상호작용을 통해 NSD2(IC50 170nM)를 억제합니다. NSC 663284 Chemical Structure
  15. GC11561 NSC 95397

    Cdc25 Inhibitor IV, PTP Inhibitor XXIX

     NSC 95397은 강력한 선택적 Cdc25 이중 특이성 인산분해효소 억제제(Ki=32 nM(Cdc25A), 96 nM(Cdc25B), 40 nM(Cdc25C); IC50=22.3 nM(인간 Cdc25A), 56.9 nM(Cdc25B)). NSC 95397은 MKP-1 및 ERK1/2 경로를 통해 결장암 세포에서 mitogen-activated protein kinase phosphatase-1(MKP-1)을 억제하고 증식을 억제하고 세포 사멸을 유도합니다. NSC 95397 Chemical Structure
  16. GC16958 Okadaic acid

    단백질 인산화효소의 강력한 억제제

     Okadaic acid Chemical Structure
  17. GC16900 PRL-3 Inhibitor

    BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

     PRL-3 억제제는 IC50이 0.9 μ인 강력한 PRL-3 억제제입니다. PRL-3 억제제는 세포 기반 분석에서 감소된 침습을 보여줍니다. PRL-3 Inhibitor Chemical Structure
  18. GC15120 PTP Inhibitor I

    α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II

     PTP 억제제 I 42의 Ki를 갖는 PTP1B 억제제 μM. PTP Inhibitor I Chemical Structure
  19. GC15804 PTP Inhibitor II

    α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II

     PTP 억제제 II는 항혈관신생 효과가 있는 단백질 티로신 포스파타제(PTP) 억제제입니다. PTP Inhibitor II Chemical Structure
  20. GC15969 PTP Inhibitor IV

    Protein Tyrosine Phosphatase Inhibitor IV

     PTP inhibitor PTP Inhibitor IV Chemical Structure
  21. GC13442 Sanguinarine chloride Sanguinaria Canadensis의 뿌리에서 추출한 벤조페난트리딘 알칼로이드인 Sanguinarine(Sanguinarin) 클로라이드는 활성산소(ROS) 생성을 활성화하여 세포자멸사를 자극할 수 있습니다. Sanguinarine에 의한 세포 사멸은 JNK 및 NF-κB의 활성화와 관련이 있습니다. Sanguinarine chloride Chemical Structure
  22. GC12498 Sephin1

    NSC 65390

     Sephin1((E/Z)-Sephin1)은 포스파타제 조절 소단위 PPP1R15A(R15A)의 선택적 억제제입니다. Sephin1 Chemical Structure
  23. GC11381 Tautomycetin Tautomycetin은 잠재적인 세포자멸사 유도 활성을 가진 강력하고 특이적인 PP1 억제제입니다. Tautomycetin Chemical Structure
  24. GC11806 β-Glycerophosphate (sodium salt hydrate)

    Glycerol 2-Phosphate

    β-글리세로인산 (나트륨 염 수화물)은 인산효소 억제제입니다.

     β-Glycerophosphate (sodium salt hydrate) Chemical Structure

23 Item(s)

페이지 당

내림차순