>> Signaling Pathways >> Immunology/Inflammation

Immunology/Inflammation

The immune and inflammation-related pathway including the Toll-like receptors pathway, the B cell receptor signaling pathway, the T cell receptor signaling pathway, etc.

Toll-like receptors (TLRs) play a central role in host cell recognition and responses to microbial pathogens. TLR4 initially recruits TIRAP and MyD88. MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-stage activation of NF-κB and MAP kinases [1]. TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. TBK1 and IKKi catalyze the phosphorylation of IRF3, leading to the expression of type I IFN [2].

BCR signaling is initiated through ligation of mIg under conditions that induce phosphorylation of the ITAMs in CD79, leading to the activation of Syk. Once Syk is activated, the BCR signal is transmitted via a series of proteins associated with the adaptor protein B-cell linker (Blnk, SLP-65). Blnk binds CD79a via non-ITAM tyrosines and is phosphorylated by Syk. Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton’s tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) [3]. Following the assembly of the BCR-signalosome, GRB2 binds and activates the Ras-guanine exchange factor SOS, which in turn activates the small GTPase RAS. The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 [4]. After stimulation of BCR, CD19 is phosphorylated by Lyn. Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream [5].

Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). Once TCR connected with its ligand, the ζ-chain–associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. Once stimulation, Zap-70 forms complexes with several molecules including SLP-76; and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) [6]. Two MAPK kinases, MKK4 and MKK7, have been reported to be the primary activators of JNK. MKK3, MKK4, and MKK6 are activators of P38 MAP kinase [7]. MAP kinase pathways are major pathways induced by TCR stimulation, and they play a key role in T-cell responses.

Phosphoinositide 3-kinase (PI3K) binds to the cytosolic domain of CD28, leading to conversion of PIP2 to PIP3, activation of PKB (Akt) and phosphoinositide-dependent kinase 1 (PDK1), and subsequent signaling transduction [8].

 

References

[1] Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J]. Nature immunology, 2010, 11(5): 373-384.

[2] Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J]. Immunity, 2011, 34(5): 637-650.

[3] Packard T A, Cambier J C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation[J]. F1000Prime Rep, 2013, 5(40.10): 12703.

[4] Zhong Y, Byrd J C, Dubovsky J A. The B-cell receptor pathway: a critical component of healthy and malignant immune biology[C]//Seminars in hematology. WB Saunders, 2014, 51(3): 206-218.

[5] Baba Y, Matsumoto M, Kurosaki T. Calcium signaling in B cells: regulation of cytosolic Ca 2+ increase and its sensor molecules, STIM1 and STIM2[J]. Molecular immunology, 2014, 62(2): 339-343.

[6] Adachi K, Davis M M. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells[J]. Proceedings of the National Academy of Sciences, 2011, 108(4): 1549-1554.

[7] Rincón M, Flavell R A, Davis R A. The Jnk and P38 MAP kinase signaling pathways in T cell–mediated immune responses[J]. Free Radical Biology and Medicine, 2000, 28(9): 1328-1337.

[8] Bashour K T, Gondarenko A, Chen H, et al. CD28 and CD3 have complementary roles in T-cell traction forces[J]. Proceedings of the National Academy of Sciences, 2014, 111(6): 2241-2246.

Targets for  Immunology/Inflammation

Products for  Immunology/Inflammation

  1. Cat.No. 상품명 정보
  2. GC41207 17(R)-HDHA Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA  Chemical Structure
  3. GC49178 17(R)-Protectin D1 An aspirin-triggered epimer of protectin D1 17(R)-Protectin D1  Chemical Structure
  4. GC41951 17(R)-Resolvin D1

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

    17(R)-Resolvin D1  Chemical Structure
  5. GC41227 17(R)-Resolvin D1 methyl ester 17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM). 17(R)-Resolvin D1 methyl ester  Chemical Structure
  6. GC45307 17(R)-Resolvin D3   17(R)-Resolvin D3  Chemical Structure
  7. GC41952 17(R)-Resolvin D4 17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 . 17(R)-Resolvin D4  Chemical Structure
  8. GC41208 17(S)-HDHA 17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. 17(S)-HDHA  Chemical Structure
  9. GC40975 17(S)-HpDHA 17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. 17(S)-HpDHA  Chemical Structure
  10. GC41958 17-hydroxy Venturicidin A 17-하이드록시 벤투리시딘 A(YP-02259L-C)는 항균 화합물입니다. 17-하이드록시 벤투리시딘 A는 두 개의 테스트된 사상균(Verticillium dahlia 및 Fusarium sp. 17-hydroxy Venturicidin A  Chemical Structure
  11. GC41980 18-carboxy dinor Leukotriene B4 18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. 18-carboxy dinor Leukotriene B4  Chemical Structure
  12. GC41982 19,20-Epoxycytochalasin C 사이토칼라신인 19,20-에폭시사이토칼라신 C는 Nemania sp. 19,20-Epoxycytochalasin C  Chemical Structure
  13. GC41983 19,20-Epoxycytochalasin D 사이토칼라신인 19,20-에폭시사이토칼라신 D는 Nemania sp. 19,20-Epoxycytochalasin D  Chemical Structure
  14. GC41160 1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-dihomo Prostaglandin E2  Chemical Structure
  15. GC38728 1V209 1V209(TLR7 작용제 T7)는 톨 유사 수용체 7(TLR7) 작용제이며 항종양 효과가 있습니다. 1V209는 다양한 다당류와 결합하여 수용성을 향상시키고 효능을 높이며 낮은 독성을 유지할 수 있습니다. 1V209  Chemical Structure
  16. GC52501 2',3'-Dideoxyadenosine 5'-triphosphate (lithium salt) An inhibitor of reverse transcriptases and DNA polymerases 2',3'-Dideoxyadenosine 5'-triphosphate (lithium salt)  Chemical Structure
  17. GC67628 2',7'-Dichlorofluorescein 2',&7#39;-디클로로플루오레세인은 반응성 산소종(ROS) 측정을 위한 형광 프로브(Ex\u003d496nm 및 Em\u003d525nm) 역할을 합니다.821d96072c2d58d8970e76f526b0f6b8 2',7'-Dichlorofluorescein  Chemical Structure
  18. GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094 2′-C-β-Methylguanosine  Chemical Structure
  19. GC49514 2′-Deoxyuridine-d2 An internal standard for the quantification of 2’-deoxyuridine 2′-Deoxyuridine-d2  Chemical Structure
  20. GC52122 2’-Deoxyadenosine-5’-diphosphate (sodium salt) A nucleotide diphosphate 2’-Deoxyadenosine-5’-diphosphate (sodium salt)  Chemical Structure
  21. GC46508 2',2'-Difluoro-2'-deoxyuridine An active metabolite of gemcitabine 2',2'-Difluoro-2'-deoxyuridine  Chemical Structure
  22. GC42079 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescein diacetate(DCFH-DA)는 세포 투과성 형광 프로브입니다. 2',7'-Dichlorofluorescein diacetate  Chemical Structure
  23. GC41281 2'-C-Methyladenosine 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 μM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 μM. 2'-C-Methyladenosine  Chemical Structure
  24. GC42080 2'2'-cGAMP (sodium salt) 2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. 2'2'-cGAMP (sodium salt)  Chemical Structure
  25. GC42090 2'3'-cGAMP (sodium salt)

    2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.

    2'3'-cGAMP (sodium salt)  Chemical Structure
  26. GC40415 2,3-dinor-11β-Prostaglandin F2α 2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively. 2,3-dinor-11β-Prostaglandin F2α  Chemical Structure
  27. GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols 2,3-Oxidosqualene  Chemical Structure
  28. GC68044 2,4,6-Trihydroxybenzaldehyde 2,4,6-Trihydroxybenzaldehyde  Chemical Structure
  29. GC68452 2,4,6-Triiodophenol 2,4,6-Triiodophenol  Chemical Structure
  30. GC46522 2,4-Dichlorobenzenesulfonyl chloride A heterocyclic building block 2,4-Dichlorobenzenesulfonyl chloride  Chemical Structure
  31. GC42076 2,5-Deoxyfructosazine (hydrochloride) 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. 2,5-Deoxyfructosazine (hydrochloride)  Chemical Structure
  32. GC39325 2,5-Dihydroxyacetophenone Rehmanniae Radix Preparata에서 분리된 2,5-Dihydroxyacetophenone은 ERK1/2 및 NF-κB 신호 전달 경로를 차단하여 활성화된 대식세포에서 염증 매개체의 생성을 억제합니다. 2,5-Dihydroxyacetophenone  Chemical Structure
  33. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO 2,5-Dihydroxycinnamic Acid phenethyl ester  Chemical Structure
  34. GC46502 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide An antimicrobial agent 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide  Chemical Structure
  35. GC42112 2-Acetyl-5-tetrahydroxybutyl Imidazole Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl Imidazole  Chemical Structure
  36. GC46533 2-Amino-6-chloropurine A precursor in the synthesis of nucleoside analogs 2-Amino-6-chloropurine  Chemical Structure
  37. GC52029 2-Aminoflubendazole 2-아미노플루벤다졸은 벤지미다졸의 대사산물입니다. 2-Aminoflubendazole  Chemical Structure
  38. GC42123 2-Aminopurine (hydrochloride) 2-아미노퓨린(염산염)은 구아노신의 형광 유사체입니다. 2-Aminopurine (hydrochloride)  Chemical Structure
  39. GC64739 2-Aminoquinoline 2-아미노퀴놀린(2-퀴놀린아민)은 생체이용 가능한 nNOS 억제제로서 유망한 화합물이지만 낮은 인간 nNOS 억제, 인간 eNOS에 대한 낮은 선택성 및 다른 CNS 표적에 대한 상당한 결합으로 인해 어려움을 겪고 있습니다. 2-Aminoquinoline  Chemical Structure
  40. GC42135 2-chloro Palmitic Acid 염증성 지질 매개체인 2-클로로팔미트산은 단백질 팔미토일화를 방해하고, ER-스트레스 마커를 유도하고, ER ATP 함량을 감소시키며, IL-6 및 IL-8.2-클로로팔미트산의 전사 및 분비를 활성화합니다. 막 전위를 유도하고 프로카스파제-3 및 PARP 절단을 유도합니다. 2-클로로 팔미트산은 혈액-뇌 장벽(BBB)을 가로질러 인간 뇌 내피 세포주 hCMEC/D3에서 ER- 및 미토콘드리아 기능을 손상시킬 수 있습니다. 2-chloro Palmitic Acid  Chemical Structure
  41. GC42136 2-chloro Stearic Acid 2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate. 2-chloro Stearic Acid  Chemical Structure
  42. GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin. 2-deoxy-Artemisinin  Chemical Structure
  43. GC40634 2-epi-Abamectin 2-epi-Abamectin is a degradation product of abamectin. 2-epi-Abamectin  Chemical Structure
  44. GC46544 2-Fluoro-4-iodo benzonitrile A building block 2-Fluoro-4-iodo benzonitrile  Chemical Structure
  45. GC45912 2-heptyl-3-hydroxy-4(1H)-Quinolone A bacterial quorum-sensing signaling molecule 2-heptyl-3-hydroxy-4(1H)-Quinolone  Chemical Structure
  46. GC18391 2-hydroxy Decanoic Acid

    2-hydroxy Decanoic acid is a fatty acid found in the lipophilic portion of the lipopolysaccharide fraction of P.

    2-hydroxy Decanoic Acid  Chemical Structure
  47. GC42166 2-hydroxy Myristic Acid 2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax. 2-hydroxy Myristic Acid  Chemical Structure
  48. GC42171 2-hydroxy Stearic Acid methyl ester 2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. 2-hydroxy Stearic Acid methyl ester  Chemical Structure
  49. GC40944 2-hydroxy-6-Methylbenzoic Acid 2-hydroxy-6-Methylbenzoic acid is a constituent of G. 2-hydroxy-6-Methylbenzoic Acid  Chemical Structure
  50. GC48910 2-Hydroxyanthraquinone 천연 화합물인 2-하이드록시안트라퀴논은 항종양 및 면역억제 활성을 가지고 있습니다. 2-Hydroxyanthraquinone  Chemical Structure
  51. GC17084 2-Imino-4-methylpiperidine (acetate) 2-이미노-4-메틸피페리딘(아세테이트)은 IC50이 0.1 μM,NOS6(NOS6μ, 인간#8956, 인간8778, he8778에 대해 87778)인 강력한 경구 활성 NO 합성효소(NOS) 이소폼 억제제입니다. hnNOS. 2-Imino-4-methylpiperidine (acetate)  Chemical Structure
  52. GC16664 2-Iminobiotin 2-이미노비오틴(Guanidinobiotin)은 비오틴(비타민 H 또는 B7) 유사체입니다. 2-Iminobiotin  Chemical Structure
  53. GC39326 2-Iminobiotin hydrobromide 2-이미노비오틴 하이드로브로마이드(Guanidinobiotin hydrobromide)는 비오틴(비타민 H 또는 B7) 유사체입니다. 2-Iminobiotin hydrobromide  Chemical Structure
  54. GC12166 2-Iminopiperidine hydrochloride iNOS inhibitor 2-Iminopiperidine hydrochloride  Chemical Structure
  55. GC52140 2-Methoxyhydroquinone 2-Methoxyhydroquinone  Chemical Structure
  56. GC42186 2-nonyl-3-hydroxy-4-Quinolone 2-nonyl-3-hydroxy-4-Quinolone is a quinolone compound produced by P. 2-nonyl-3-hydroxy-4-Quinolone  Chemical Structure
  57. GC52445 2-nonyl-3-hydroxy-4-Quinolone-d4 An internal standard for the quantification of 2-nonyl-3-hydroxy-4-quinolone 2-nonyl-3-hydroxy-4-Quinolone-d4  Chemical Structure
  58. GC46553 2-Nonylquinolin-4(1H)-one A quinolone alkaloid with diverse biological activities 2-Nonylquinolin-4(1H)-one  Chemical Structure
  59. GC52446 2-Nonylquinolin-4(1H)-one-d4 An internal standard for the quantification of 2-nonylquinolin-4(1H)-one 2-Nonylquinolin-4(1H)-one-d4  Chemical Structure
  60. GC49786 2-NP-AOZ 2-NP-AOZ는 AOZ의 2-니트로페닐 유도체입니다. 2-NP-AOZ  Chemical Structure
  61. GC49283 2-O-(α-D-Glucopyranosyl)glycerol A compatible solute 2-O-(α-D-Glucopyranosyl)glycerol  Chemical Structure
  62. GC35095 2-Phospho-L-ascorbic acid trisodium salt 2-Phospho-L-ascorbic acid trisodium salt(2-Phospho-L-ascorbic acid trisodium)는 콜라겐 형성과 발현을 자극할 수 있는 오래 지속되는 비타민 C 유도체입니다. 2-Phospho-L-ascorbic acid trisodium salt  Chemical Structure
  63. GC17951 2-TEDC 5-, 12-, and 15-lipoxygenase inhibitor 2-TEDC  Chemical Structure
  64. GC68043 2-tert-Butyl-1,4-benzoquinone 2-tert-Butyl-1,4-benzoquinone  Chemical Structure
  65. GC42193 2-Thenoyltrifluoroacetone 2-Thenoyltrifluoroacetone은 킬레이트제입니다. 2-Thenoyltrifluoroacetone  Chemical Structure
  66. GC15355 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator 2-Trifluoromethyl-2'-methoxychalcone  Chemical Structure
  67. GC40960 20α-dihydro Prednisolone 20α-dihydro Prednisolone is a metabolite of prednisolone. 20α-dihydro Prednisolone  Chemical Structure
  68. GC42082 20-carboxy Leukotriene B4 20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. 20-carboxy Leukotriene B4  Chemical Structure
  69. GC41387 20-hydroxy Arachidic Acid 20-hydroxy Arachidic acid is a hydroxylated fatty acid that has been found in the suberin component of silver birch (B. 20-hydroxy Arachidic Acid  Chemical Structure
  70. GC41421 20-hydroxy Leukotriene B4 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. 20-hydroxy Leukotriene B4  Chemical Structure
  71. GC60467 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 21-아세톡시프레그나-1,4,9(11),16-테트라엔-3,20-디온은 델타 9,11 스테로이드 합성의 중간체입니다(예: Vamorolone) 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione  Chemical Structure
  72. GC42087 21-desacetyl Deflazacort 21-desacetyl Deflazacort is the active glucocorticoid derived from the prodrug deflazacort. 21-desacetyl Deflazacort  Chemical Structure
  73. GC40571 24(S),25-epoxy Cholesterol

    24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.

    24(S),25-epoxy Cholesterol  Chemical Structure
  74. GC49365 25-Desacetyl Rifampicin A major active metabolite of rifampicin 25-Desacetyl Rifampicin  Chemical Structure
  75. GC48482 28-Acetylbetulin A lupane triterpenoid with anti-inflammatory and anticancer activities 28-Acetylbetulin  Chemical Structure
  76. GC48503 28-Deoxybetulin methyleneamine A derivative of betulin 28-Deoxybetulin methyleneamine  Chemical Structure
  77. GC46549 2F-Peracetyl-Fucose 2F-Peracetyl-Fucose(1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos)는 강력한 푸코실트랜스퍼라제(FUT) 억제제로 작용합니다. 2F-Peracetyl-Fucose  Chemical Structure
  78. GC49005 2S-Eriodictyol A flavanone with antioxidant activity 2S-Eriodictyol  Chemical Structure
  79. GC25014 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs. 3',3'-cGAMP  Chemical Structure
  80. GC49122 3′-deoxy Thymidine An antiviral nucleoside analog 3′-deoxy Thymidine  Chemical Structure
  81. GC49871 3’-Azido-2’,3’-dideoxyuridine An antiviral nucleoside analog 3’-Azido-2’,3’-dideoxyuridine  Chemical Structure
  82. GC34451 3',4'-Dihydroxyflavonol 3',4'-디히드록시플라보놀(DiOHF)은 효과적인 항산화제로서 당뇨병 쥐의 장간막 동맥에서 과산화물을 감소시키고 산화질소(NO) 기능을 향상시킵니다. 3',4'-Dihydroxyflavonol  Chemical Structure
  83. GC42312 3'-Sialyllactose (sodium salt) 3'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 3 position. 3'-Sialyllactose (sodium salt)  Chemical Structure
  84. GC42242 3'-sulfo Galactosylsphingosine (ammonium salt) 3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. 3'-sulfo Galactosylsphingosine (ammonium salt)  Chemical Structure
  85. GC42245 3'3'-cGAMP (sodium salt) 3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. 3'3'-cGAMP (sodium salt)  Chemical Structure
  86. GN10006 3,4-Dihydroxybenzaldehyde 3,4-Dihydroxybenzaldehyde  Chemical Structure
  87. GC33992 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 3,4-Dimethoxycinnamic acid(O-Methylferulic acid)(O-Methylferulic acid)는 Securidaca inappendiculata Hassk에서 추출 정제한 단량체입니다. 3,4-Dimethoxycinnamic acid (O-Methylferulic acid)  Chemical Structure
  88. GC61673 3,5-Di-tert-butylphenol 3,5-Di-tert-부틸페놀은 항생물막 및 항진균 활성을 갖는 휘발성 유기 화합물입니다. 3,5-Di-tert-butylphenol  Chemical Structure
  89. GC46577 3,5-Dihydroxybenzaldehyde A building block 3,5-Dihydroxybenzaldehyde  Chemical Structure
  90. GC64762 3,6-Dihydroxyflavone 3,6-Dihydroxyflavone은 항암제입니다. 3,6-디히드록시플라본은 용량 및 시간에 따라 세포 생존력을 감소시키고 카스파제 캐스케이드를 활성화하여 폴리(ADP-리보스) 폴리머라제(PARP)를 절단함으로써 세포자멸사를 유도합니다. 3,6-Dihydroxyflavone은 세포 내 산화 스트레스와 지질 과산화를 증가시킵니다. 3,6-Dihydroxyflavone  Chemical Structure
  91. GC49169 3,8’-Biapigenin 3,8’-Biapigenin은 Hypericum perforatum L.의 비플라본입니다. 3,8’-Biapigenin  Chemical Structure
  92. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides 3-(3-Hydroxyphenyl)propionic Acid sulfate  Chemical Structure
  93. GC14282 3-acetyl-11-keto-β-Boswellic Acid 3-acetyl-11-keto-β-Boswellic Acid(Acetyl-11-keto-β-boswellic acid)는 Boswellia serrate 추출물과 새로운 Nrf2 활성화제에서 추출한 활성 트리테르페노이드 화합물입니다. 3-acetyl-11-keto-β-Boswellic Acid  Chemical Structure
  94. GC68081 3-Amino-1,2,4-triazine 3-Amino-1,2,4-triazine  Chemical Structure
  95. GC46583 3-Amino-2,6-Piperidinedione An active metabolite of (±)-thalidomide 3-Amino-2,6-Piperidinedione  Chemical Structure
  96. GC52129 3-Amino-5-hydroxybenzoic Acid 3-Amino-5-hydroxybenzoic Acid  Chemical Structure
  97. GC49849 3-Aminosalicylic Acid A salicylic acid derivative 3-Aminosalicylic Acid  Chemical Structure
  98. GC38208 3-Bromo-7-nitroindazole A potent inhibitor of nNOS 3-Bromo-7-nitroindazole  Chemical Structure
  99. GC10385 3-Bromo-7-nitroindazole 3-브로모-7-니트로인다졸은 eNOS 또는 유도성 산화질소 합성효소(iNOS)보다 뉴런 산화질소 합성효소(nNOS)의 더 강력하고 선택적인 억제제입니다. 3-Bromo-7-nitroindazole  Chemical Structure
  100. GC42259 3-Deaza-2'-deoxyadenosine 3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM. 3-Deaza-2'-deoxyadenosine  Chemical Structure
  101. GC62794 3-Demethylcolchicine 콜히친 대사 산물인 3-Demethylcolchicine은 라디칼 소거에 참여할 수 있는 탄소 고리에 히드록시기를 갖고 있으며 카라기닌 부종을 현저하게 억제합니다. 3-Demethylcolchicine  Chemical Structure

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