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홈 >> Signaling Pathways >> Others >> MDR multidrug resistance

MDR multidrug resistance

MDR (multidrug resistance) is a property that first identified in tumor cell, hat the resistance of tumor cell is to a variety of chemotherapy agent due to active efflux via transporter proteins.

Products for  MDR multidrug resistance

  1. Cat.No. 상품명 정보
  2. GC45246 (-)-Chaetominine

    (-)-Chaetominine

     (-)-Chaetominine은 알칼로이드 대사 산물입니다. (-)-케토미닌은 인간 백혈병 K562 및 결장암 SW1116 세포주에 대해 세포독성을 갖는다. (-)-케토미닌은 K562/Adr 인간 백혈병 세포에서 PI3K/Akt/Nrf2 신호 전달 경로를 억제하여 MRP1 매개 약물 내성을 감소시킵니다. (-)-Chaetominine Chemical Structure
  3. GC41865 10'-Desmethoxystreptonigrin 10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. 10'-Desmethoxystreptonigrin Chemical Structure
  4. GC45324 2,5-dimethyl Celecoxib

    DMC

       2,5-dimethyl Celecoxib Chemical Structure
  5. GC91154 33-BCRP Inhibitor

    BCRP 억제제

     33-BCRP Inhibitor Chemical Structure
  6. GC91135 4-(3,4-Difluorobenzo)curcumin

    항기생충 및 항암 활성을 가진 반합성 쿠마린

     4-(3,4-Difluorobenzo)curcumin Chemical Structure
  7. GC42616 7-oxo Staurosporine

    BMY 41950, RK-1409

    7-oxo Staurosporine is an antibiotic originally isolated from S.

     7-oxo Staurosporine Chemical Structure
  8. GC49275 8-Oxycoptisine

    8-Oxocoptisine

     8-옥시콥티신은 항암 활성이 있는 천연 프로토베르베린 알칼로이드입니다. 8-Oxycoptisine Chemical Structure
  9. GC46809 Afatinib-d6

    BIBW 2992 D6

     Afatinib-d6(BIBW 2992 D6)은 Afatinib로 표시된 중수소입니다. Afatinib(BIBW 2992)는 비가역적 EGFR 계열 억제제입니다. Afatinib-d6 Chemical Structure
  10. GC42806 Andrastin A

    NSC 697452

     Andrastin A is a meroterpenoid farnesyltransferase inhibitor. Andrastin A Chemical Structure
  11. GC43004 C10 Ceramide (d18:1/10:0)

    N-decanoyl-D-erythro-Sphingosine

    C10 ceramide is an endogenous, bioactive sphingolipid produced by ceramide synthase.

     C10 Ceramide (d18:1/10:0) Chemical Structure
  12. GC43060 C2 Adamantanyl Globotriaosylceramide (d18:1/2:0) C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. C2 Adamantanyl Globotriaosylceramide (d18:1/2:0) Chemical Structure
  13. GC45395 Cabazitaxel-d9

    XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9

     카바지탁셀-d9는 카바지탁셀로 표지된 중수소입니다. 카바지탁셀은 잠재적인 항종양 활성을 가진 천연 탁소이드 10-데아세틸바카틴 III의 반합성 유도체입니다. Cabazitaxel-d9 Chemical Structure
  14. GC45679 Carubicin

    Antibiotic R 588A, Carminomycin, NCI 180024, NSC 180024

     Carubicin(Carminomycin)은 미생물 유래 화합물입니다. Carubicin Chemical Structure
  15. GC40795 CAY10503 CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 Chemical Structure
  16. GC18901 CAY10647 CAY10647 is an aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg). CAY10647 Chemical Structure
  17. GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

    Iron Salophene Complex, N,N'-o-Phenylenebis(salicylideneaminato)iron(III) Chloride

     An inducer of ferroptosis Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Chemical Structure
  18. GC90543 EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt)

    PKC 억제제

     EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt) Chemical Structure
  19. GC46004 Evoxanthine

    NSC 407812

     An alkaloid Evoxanthine Chemical Structure
  20. GC91152 Flavokawain 1i

    항암 및 항바이러스 활성을 가진 플라보카완 유도체

     Flavokawain 1i Chemical Structure
  21. GC90660 Fz25

    트리아졸 수정 스테롤과 항암제

     Fz25 Chemical Structure
  22. GC49106 Gentisein

    NSC 329491

     Mangiferin의 주요 대사산물인 Gentisein(NSC 329491)은 4.7μM의 IC50 값으로 가장 강력한 세로토닌 흡수 억제를 나타냅니다. Gentisein Chemical Structure
  23. GC47409 Glycocholic Acid-d4

    Cholylglycine-d4, GCA-d4

     Glycocholic Acid-d4는 Glycocholic acid로 표시된 중수소입니다. 글리코콜린산은 항암 활성을 갖는 담즙산으로 펌프 저항 관련 및 비펌프 저항 관련 경로를 표적으로 합니다. Glycocholic Acid-d4 Chemical Structure
  24. GC91057 HP661

    미토콘드리아 복합체 I 억제제

     HP661 Chemical Structure
  25. GC91403 HR68

    PP21

    HR68는 항암제이며, 페노피브릭 산의 과산화작용 활성제 파생물인 peroxisome proliferator-activated receptor (PPAR) 작용제입니다.

     HR68 Chemical Structure
  26. GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent Indium (III) thiosemicarbazone 5b Chemical Structure
  27. GC44129 MC 70 MC 70은 EC50이 0.69μM인 강력한 비선택적 P-당단백질(P-gp) 억제제입니다. MC 70은 ABC 수송체 억제제 및 항암제입니다. MC 70은 ABCB1, ABCG2 및 ABCC1과 상호 작용합니다. MC 70 Chemical Structure
  28. GC48479 Migrastatin

    (+)-Migrastatin

     A fungal metabolite with antimuscarinic and anticancer activities Migrastatin Chemical Structure
  29. GC44195 Milbemycin A4 oxime

    5-Ketomilbemycin A4 oxime, 5-Oxomilbemycin A4 5-oxime

     Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime, compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime Chemical Structure
  30. GC41564 MPT0B014 An inhibitor of tubulin polymerization MPT0B014 Chemical Structure
  31. GC19270 Olmutinib Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. Olmutinib Chemical Structure
  32. GC45784 ONT-093

    OC 144093

     ONT-093은 P-당단백질 펌프의 강력한 억제제입니다. ONT-093은 암 연구에 대한 가능성이 있습니다. ONT-093 Chemical Structure
  33. GC49251 Oxaliplatin-d10

    Lipoxal-d10

     An internal standard for the quantification of oxaliplatin Oxaliplatin-d10 Chemical Structure
  34. GC44613 PF-6274484 PF-6274484는 EGFR-L858R/T790M 및 WT EGFR에 대해 각각 0.14nM 및 0.18nM의 Kis를 갖는 강력한 EGFR 억제제입니다. PF-6274484는 각각 6.6 및 5.8 nM의 IC50으로 H1975 종양 세포에서 EGFR-L858R/T790M 자가인산화를 억제하고 A549 종양 세포에서 EGFR WT를 억제합니다. PF-6274484 Chemical Structure
  35. GC44615 PGP-4008 PGP-4008은 특정 P-당단백질(Pgp) 억제제입니다. PGP-4008은 독소루비신과 함께 제공될 때 쥐 동계 Pgp 매개 다중 약물 내성(MDR) 고형 종양 모델에서 종양 성장을 억제합니다. PGP-4008 Chemical Structure
  36. GC41629 Piperafizine A 피페라피진 A(화합물 4d')는 N-모노알킬화 플리나불린 유도체입니다. 항암제. Piperafizine A Chemical Structure
  37. GC52455 Pixantrone-d8 (maleate) An internal standard for the quantification of pixantrone Pixantrone-d8 (maleate) Chemical Structure
  38. GC52104 Ponatinib (hydrochloride)

    AP 24534

     포나티닙(AP24534) 염산염은 포나티닙의 염산염입니다. 포나티닙은 Abl, PDGFRα, VEGFR2, FGFR1 및 Src에 대해 각각 IC50이 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, 5.4 nM인 경구 활성 다중 표적 키나제 억제제입니다. Ponatinib (hydrochloride) Chemical Structure
  39. GC17403 Pyronaridine Tetraphosphate

    PND

    An antimalarial agent

     Pyronaridine Tetraphosphate Chemical Structure
  40. GC44821 Reversin 121 Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. Reversin 121 Chemical Structure
  41. GC91096 S-72

    미세관 폴리머화의 억제제

     S-72 Chemical Structure
  42. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  43. GC48119 Suprafenacine

    SML1493

     An inhibitor of tubulin polymerization with anticancer activity Suprafenacine Chemical Structure
  44. GC48219 Ulipristal Acetate-d6

    CDB-2914-d6

     An internal standard for the quantification of ulipristal acetate Ulipristal Acetate-d6 Chemical Structure
  45. GC49308 Ungeremine

    Lycobetaine

     A betaine-type alkaloid with diverse biological activities Ungeremine Chemical Structure
  46. GC91435 YCH1899

    YCH1899는 poly(ADP-ribose) polymerase 1 (PARP1) 및 PARP2의 억제제입니다. (IC50s = 1). 이것은 PARP3, -4, -5A, -5B, -6, -7, -10 및 -12보다 PARP1과 PARP2에 선택적입니다. (IC50s = 1-14.1 nM).

     YCH1899 Chemical Structure

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