RU 24969 hemisuccinate |
| Catalog No.GC50006 |
RU 24969 헤미숙시네이트는 0.38nM의 Ki를 갖는 우선적인 5-HT1B 작용제이지만 5-HT1A 수용체(Ki=2.5nM)에 대해 상당한 친화도를 나타내고 뇌의 다른 수용체 부위에 대한 친화도가 낮습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66611-27-6
Sample solution is provided at 25 µL, 10mM.
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Potent 5-HT1A/1B and moderate 5-HT2C agonist that may also release 5-HT. Centrally active following systemic administration.
Gudermann et al (1993) Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. Mol.Pharmacol. 43 412 PMID:8450834 |Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID:10837852 |Guillaume et al (1987) Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles and study of their serotonergic and antiDArgic properties. Eur.J.Med.Chem. 22 33
| Cas No. | 66611-27-6 | SDF | |
| Canonical SMILES | OC(=O)CCC(O)=O.COC1=CC=C2NC=C(C2=C1)C1=CCNCC1.COC1=CC=C2NC=C(C2=C1)C1=CCNCC1 | ||
| Formula | C14H16N2O.½C4H6O4 | M.Wt | 287.34 |
| Solubility | DMF: slightly soluble,DMSO: slightly soluble,Ethanol: slightly soluble,PBS (pH 7.2): 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4802 mL | 17.401 mL | 34.802 mL |
| 5 mM | 696 μL | 3.4802 mL | 6.9604 mL |
| 10 mM | 348 μL | 1.7401 mL | 3.4802 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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