>>Sevoflurane

Sevoflurane

Catalog No.GC19481

A halogenated ether with anesthetic properties

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Sevoflurane Chemical Structure

Cas No.: 28523-86-6

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Sevoflurane is a halogenated ether with anesthetic properties.1 It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively).2 Sevoflurane (360 µM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an α1β2γ2 subunit composition.3 It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM).4 Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.

Reference:

[1]. Campagna, J.A., Miller, K.W., Phil, D., et al. Mechanisms of actions of inhaled anesthetics N. Engl. J. Med. 348(21), 2110-2124 (2003).
[2]. Krasowski, M.D., and Harrison, N.L. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations Br. J. Pharmacol. 129(4), 731-743 (2000).
[3]. Nishikawa, K., and Harrison, N.L. The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: Effects of TM2 mutations in the alpha and beta subunits Anesthesiology 99(3), 678-684 (2003).
[4]. Rada, E.M., Tharakan, E.C., and Flood, P. Volatile anesthetics reduce agonist affinity at nicotinic acetylcholine receptors in the brain Anesth. Analg. 96(1), 108-111 (2003).

Chemical Properties

Cas No. 28523-86-6 SDF
Chemical Name 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propane
Canonical SMILES FCOC(C(F)(F)F)C(F)(F)F
Formula C4H3F7O M.Wt 200.1
Solubility DMF: miscible,DMSO: miscible,Ethanol: miscible,PBS (pH 7.2): miscible Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.9975 mL 24.9875 mL 49.975 mL
5 mM 0.9995 mL 4.9975 mL 9.995 mL
10 mM 0.4998 mL 2.4988 mL 4.9975 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Sevoflurane

Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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