>>Signaling Pathways>> PROTAC>> Ligand for Target Protein for PROTAC>>SLF TFA

SLF TFA

Catalog No.GC61461

SLF TFA는 FKBP51에 대한 친화도가 3.1μM이고 FKBP12에 대한 IC50이 2.6μM인 FK506 결합 단백질(FKBP)에 대한 합성 리간드입니다. SLF TFA는 PROTAC의 합성에 사용할 수 있습니다.

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SLF TFA Chemical Structure

Cas No.: 2378802-47-0

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$98.00
재고 있음
5 mg
US$70.00
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10 mg
US$130.00
재고 있음
50 mg
US$519.00
재고 있음
100 mg
US$862.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3].

Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation[3].

[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go• Front Pharmacol. 2018 Dec 5;9:1425. [2]. Wu X, et al. Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library. ACS Comb Sci. 2011 Sep 12;13(5):486-95. [3]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.

Chemical Properties

Cas No. 2378802-47-0 SDF
Canonical SMILES OC(C(F)(F)F)=O.CCC(C)(C)C(C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(N)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)=O)=O
Formula C32H41F3N2O8 M.Wt 638.67
Solubility DMSO: 200 mg/mL (313.15 mM) Storage 4°C, away from moisture and light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.5658 mL 7.8288 mL 15.6575 mL
5 mM 0.3132 mL 1.5658 mL 3.1315 mL
10 mM 0.1566 mL 0.7829 mL 1.5658 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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