L67 (Synonyms: DNA Ligase Inhibitor) |
| Catalog No.GC18186 |
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 uM for human DNA ligase I and human ligase IIIβ).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 325970-71-6
Sample solution is provided at 25 µL, 10mM.
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L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 uM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 uM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 uM.
Review for L67
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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