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L6H21

Catalog No.GC49560

L6H21, a Chalcone derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor.

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L6H21 Chemical Structure

Cas No.: 24533-47-9

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1 mg
$43.00
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5 mg
$171.00
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10 mg
$321.00
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25 mg
$536.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

L6H21 is an inhibitor of myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96).1 It binds to MD-2 (Kd = 33.3 µM in a cell-free assay) and inhibits the protein-protein interaction between MD-2 and toll-like receptor 4 (TLR4) in LPS-stimulated ECV304 cells. L6H21 (10 µM) decreases the migration of LPS-stimulated HCT116 colon cancer cells.2 It inhibits LPS-induced increases in the production of TNF-α and IL-6 in mouse primary macrophages (IC50s = 6.17 and 7.72 µM, respectively), as well as increases survival in a mouse model of LPS-induced sepsis.1 L6H21 (40 mg/kg) increases cardiac levels of glutathione peroxidase 4 (GPX4) and decreases cardiac mitochondrial reactive oxygen species (ROS) in rats fed a high-fat diet.3

1.Wang, Y., Shan, X., Chen, G., et al.MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsisBr. J. Pharmacol.172(17)4391-4405(2015) 2.Rajamanickam, V., Yan, T., Xu, S., et al.Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasisInt. J. Biol. Sci.16(8)1288-1302(2020) 3.Sumneang, N., Oo, T.T., Singhanat, K., et al.Inhibition of myeloid differentiation factor 2 attenuates cardiometabolic impairments via reducing cardiac mitochondrial dysfunction, inflammation, apoptosis and ferroptosis in prediabetic ratsBiochem. Biophys. Acta Mol. Basis Dis1868(2)166301(2021)

Chemical Properties

Cas No. 24533-47-9 SDF Download SDF
Canonical SMILES COC1=C(C=CC=C1OC)/C=C/C(C2=CC=C(C=C2)OC)=O
Formula C18H18O4 M.Wt 298.3
Solubility DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 5 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3523 mL 16.7616 mL 33.5233 mL
5 mM 0.6705 mL 3.3523 mL 6.7047 mL
10 mM 0.3352 mL 1.6762 mL 3.3523 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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