Lademirsen (Synonyms: SAR339375; RG-012) |
| Catalog No.GC65289 |
Lademirsen (SAR339375; RG-012) is a single stranded, chemically modified oligonucleotide that binds to and inhibits the function of miR-21.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1404019-95-9
Sample solution is provided at 25 µL, 10mM.
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Lademirsen (SAR339375; RG-012) is a single stranded, chemically modified oligonucleotide that binds to and inhibits the function of miR-21. Lademirsen has the potential for Alport nephropathy research[1][2].
Administration of Lademirsen (SAR339375; RG-012) to inhibit miR-21 leads to a slowed progression of renal fibrosis and an increased lifespan in Alport syndrome mouse models[1].
[1]. Ivan G Gomez, et al. Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J Clin Invest. 2015 Jan;125(1):141-56.
[2]. Chiranjib Chakraborty, et al. Therapeutic advances of miRNAs: A preclinical and clinical update. J Adv Res. 2020 Aug 29;28:127-138.
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