Home>>Signaling Pathways>> Microbiology & Virology>> Antibiotic>>Leucomycin A1

Leucomycin A1 (Synonyms: Kitasamycin A1,3-deacetyl Josamycin,Leucomycin V 4-isovalerate,9-dihydro Niddamycin,Turimycin H5)

Catalog No.GC10414

major metabolite of macrolide antibiotics

Products are for research use only. Not for human use. We do not sell to patients.

Leucomycin A1 Chemical Structure

Cas No.: 16846-34-7

Size Price Stock Qty
1mg
$512.00
In stock
5mg
$1,673.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

Leucomycin A1, a major metabolite extracted from the leucomycin complex, is a major macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis.

Leucomycin A1 is one of the more potent members of leucomycin complex. Leucomycin complex (kitasamycin) is effective against a wide spectrum of pathogens, such as Gram-positive bacteria, Gram-negative cocci, mycoplasma, and Leptospira. Leucomycin complex has been used as an animal health product for control of Gram positive bacteria, Gram negative cocci, mycoplasma, and Leptospira. Until now, little is known about the activity of individual analogues within the complex. At a concentration of 1.56μg/ml, kitasamycin inhibited all isolates of Diplococcus pneumonia [2]. Each component of leucomycins potently inhibited the growth of Gram-positive bacteria and showed not so strong activity against the Gram-negative bacteria. Each component showed the same tendency towards the antibacterial spectrum [3].

References:
[1] Hata T, Sano Y, Ohki N, et al.  Leucomycin, a new antibiotic[J]. The Journal of antibiotics, 1953, 6(2): 87-89.
[2] Balducci Y, BODEY G P.  In vitro activity of kitasamycin against gram-positive cocci[J]. The Journal of antibiotics, 1974, 27(7): 516-519.
[3] Omura S, Katagiri M, Umezawa I, et al.  Structure-biological activities relationships among leucomycins and their derivatives[J]. The Journal of antibiotics, 1968, 21(9): 532-538.

Chemical Properties

Cas No. 16846-34-7 SDF
Synonyms Kitasamycin A1,3-deacetyl Josamycin,Leucomycin V 4-isovalerate,9-dihydro Niddamycin,Turimycin H5
Chemical Name 4B-(3-methylbutanoate) leucomycin V
Canonical SMILES O=C1C[C@H]([C@@H]([C@H]([C@H](C[C@H]([C@H](/C=C/C=C/C[C@H](O1)C)O)C)CC=O)O[C@@]2(O[C@@H]([C@H]([C@@H]([C@H]2O)N(C)C)O[C@]3(C[C@@](O)([C@H]([C@@H](O3)C)OC(CC(C)C)=O)C)[H])C)[H])OC)O
Formula C40H67NO14 M.Wt 786
Solubility DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.2723 mL 6.3613 mL 12.7226 mL
5 mM 0.2545 mL 1.2723 mL 2.5445 mL
10 mM 0.1272 mL 0.6361 mL 1.2723 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Leucomycin A1

Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Leucomycin A1

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.