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LOXL2-IN-1 hydrochloride

Catalog No.GC30544

LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

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LOXL2-IN-1 hydrochloride Chemical Structure

Cas No.: 916210-98-5

Size Price Stock Qty
10mM (in 1mL DMSO)
$71.00
In stock
100mg
$65.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

LOXL2-IN-1 is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, LOXL2-IN-1 has an IC50 of 1.45 µM compared to 126 nM in the absence of blood proteins. LOXL2-IN-1 shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 µM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 µM. LOXL2-IN-1 is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 µM[1].

[1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427.

Chemical Properties

Cas No. 916210-98-5 SDF
Canonical SMILES [H]Cl.ClC1=NC=CC(CN)=C1
Formula C6H8Cl2N2 M.Wt 179.05
Solubility Water : ≥ 50 mg/mL (279.25 mM);DMSO : ≥ 33 mg/mL (184.31 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.585 mL 27.9252 mL 55.8503 mL
5 mM 1.117 mL 5.585 mL 11.1701 mL
10 mM 0.5585 mL 2.7925 mL 5.585 mL
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