Lumisterol 3 (Synonyms: L3) |
| Catalog No.GC49207 |
A photoisomer of previtamin D3
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Cas No.: 5226/1/7
Sample solution is provided at 25 µL, 10mM.
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Lumisterol 3 (L3) is a photoisomer of previtamin D3 .1 It is formed by photoisomerization of previtamin D3 in the epidermis by prolonged UVB exposure and is metabolized by the cytochrome P450 (CYP) isoform CYP11A1 in a variety of tissues to several hydroxylated metabolites, including the active metabolites 20-hydroxy L3, 24-hydroxy L3, and 20,22-dihydroxy L3.2,3
1.Slominski, A.T., Chaiprasongsuk, A., Janjetovic, Z., et al.Photoprotective droperties of vitamin D and lumisterol hydroxyderivativesCell Biochem. Biophys.78(2)165-180(2020) 2.Holick, M.F.Photosynthesis of vitamin D in the skin: Effect of environmental and life-style variablesFed. Proc.46(5)1876-1882(1987) 3.Slominski, A.T., Kim, T.-K., Hobrath, J.V., et al.Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterolsSci. Rep.7(1)11434(2017)
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