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LY 2365109 hydrochloride

Catalog No.GC11341

glycine transporter 1 (GlyT1) inhibitor

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LY 2365109 hydrochloride Chemical Structure

Cas No.: 868265-28-5

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10mg
$144.00
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50mg
$405.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

LY2365109 is a potent and selective GlyT1 inhibitors with IC50 value of 15.8 nM.target: GlyT1[1]IC 50: 15.8 nM [1]In vivo: The reference for LY2365109 is 0.3 or 30 mg/kg by PO. LY2365109 appeared slightly more potent than ALX5407 over the dose-range tested on CSF levels of glycine in the ratLY2365109 can act to potentiate NMDA function in the PFC but also mediate sustained inhibition of GlyT1 transporters in caudal areas of the brain.[1] LY2365109 increased seizure thresholds in mice. Importantly, chronic seizures in the mouse model of TLE were robustly suppressed by systemic administration of the GlyT1 inhibitor LY2365109. [2]

References:
[1]. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
[2]. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.

Chemical Properties

Cas No. 868265-28-5 SDF
Chemical Name 2-((2-(4-(benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid hydrochloride
Canonical SMILES CC(C)(C1=C(OCCN(CC(O)=O)C)C=CC(C2=CC3=C(OCO3)C=C2)=C1)C.Cl
Formula C22H27NO5.HCl M.Wt 421.91
Solubility <42.19mg/ml in DMSO; <21.1mg/ml in ethanol Storage Desiccate at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3702 mL 11.8509 mL 23.7017 mL
5 mM 0.474 mL 2.3702 mL 4.7403 mL
10 mM 0.237 mL 1.1851 mL 2.3702 mL
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