LY2140023 (Synonyms: LY2140023) |
| Catalog No.GC61016 |
LY2140023 (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039.
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Cas No.: 635318-55-7
Sample solution is provided at 25 µL, 10mM.
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LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist. LY2140023 has the potential for schizophrenia[1].
LY2140023 (orally; 3, 10, and 300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1]. Animal Model: Male Fischer rats (approximately 250 g)[1]
[1]. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70.
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