Lyso-Monosialoganglioside GM1 (ammonium salt) (Synonyms: Lysoganglioside GM1, Lyso-GM1, lyso-Monosialoganglioside GM1) |
| Catalog No.GC44102 |
Lyso-monosialoganglioside GM1 (Lyso-GM1) is a form of ganglioside GM1 that is lacking the fatty acyl group.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lyso-monosialoganglioside GM1 (Lyso-GM1) is a form of ganglioside GM1 that is lacking the fatty acyl group. Lyso-GM1 (2.5 µM) inhibits laminin-1-induced clustering of ganglioside GM1 in dorsal root ganglion (DRG) cells and also disrupts β1 integrin clustering and neurite outgrowth. It does not protect against glutamate-induced neurotoxicity in primary neuronal cultures. Elevated levels of lyso-GM1 have been found in the brain and spinal cord of patients with infantile- and late-infantile-type GM1-gangliosidosis, a neurodegenerative disorder characterized by deficiency of the enzyme β-galactosidase and accumulation of gangliosides.
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