Marbofloxacin-d8 (hydrochloride) |
Catalog No.GC52434 |
An internal standard for the quantification of marbofloxacin
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Marbofloxacin-d8 is intended for use as an internal standard for the quantification of marbofloxacin by GC- or LC-MS. Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml).1 It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively.2 Intramuscular administration of marbofloxacin (2 mg/kg) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia.3 Oral administration of marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%.4 Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.
1.Ferran, A.A., Toutain, P.L., and Bousquet-MÉlou, A.Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infectionVet. Microbiol.148(2-4)292-297(2011) 2.Spreng, M., Deleforge, J., Thomas, V., et al.Antibacterial activity of marbofloxacin. A new fluoroquinolone for veterinary use against canine and feline isolatesJ. Vet. Pharmacol. Ther.18(4)284-289(1995) 3.Lhermie, G., Ferran, A.A., AssiÉ, S., et al.Impact of timing and dosage of a fluoroquinolone treatment on the microbiological, pathological, and clinical outcomes of calves challenged with Mannheimia haemolyticaFront. Microbiol.237(7)(2016) 4.Pineda, C., Aguilera-Tejero, E., Morales, M.C., et al.Treatment of canine leishmaniasis with marbofloxacin in dogs with renal diseasePLoS One12(10)e0185981(2017)
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