Medetomidine |
Catalog No.GC13144 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86347-14-0
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
References:
[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C.Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride.Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x.
[2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C.Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus).Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012.00754.x.
[3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M.Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man.Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.
[4]. Virtanen R, Savola JM, Saano V, Nyman L.Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist.Eur J Pharmacol. 1988 May 20;150(1-2):9-14.
[5]. Stenberg D, Salvén P, Miettinen MV.Sedative action of the alpha 2-agonist medetomidine in cats.J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.
Cas No. | 86347-14-0 | SDF | |
Chemical Name | 5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole | ||
Canonical SMILES | CC1=C(C)C(C(C2=CN=CN2)C)=CC=C1 | ||
Formula | C13H16N2 | M.Wt | 200.28 |
Solubility | Soluble in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 4.993 mL | 24.965 mL | 49.9301 mL |
5 mM | 0.9986 mL | 4.993 mL | 9.986 mL |
10 mM | 0.4993 mL | 2.4965 mL | 4.993 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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