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Medetomidine Catalog No.GC13144

α2-adrenoceptor agonist

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 86347-14-0 SDF
Synonyms Domtor
Chemical Name 5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole
Canonical SMILES CC1=C(C)C(C(C2=CN=CN2)C)=CC=C1
Formula C13H16N2 M.Wt 200.28
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C.Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride.Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x.
[2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C.Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus).Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012.00754.x.
[3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M.Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man.Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.
[4]. Virtanen R, Savola JM, Saano V, Nyman L.Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist.Eur J Pharmacol. 1988 May 20;150(1-2):9-14.
[5]. Stenberg D, Salvén P, Miettinen MV.Sedative action of the alpha 2-agonist medetomidine in cats.J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.