Menaquinone-7 (Vitamin K2-7) (Synonyms: MK-7, Vitamin K2(35), Vitamin MK-7) |
| Catalog No.GC32498 |
Menaquinone-7 (Vitamin K2-7) (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors.
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Cas No.: 2124-57-4
Sample solution is provided at 25 µL, 10mM.
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Menaquinone-7 (Vitamin K2-7), a highly valuable member of the vitamin K series, has significant effects on preventing osteoporosis and cardiovascular disease besides its positive effects on blood coagulation [1].
Menaquinone-7 (10 µM) treated MC3T3E1 cells for 24, 48, 96 and 240 h, no statistical differences at 24, 48 and 96 h, the growth of MK-7 treated cells was significantly suppressed at 240 h. Menaquinone-7 increased osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells [2]. After 24 h of Menaquinone-7 administration, genes upregulated by Menaquinone-7 included tenascin C and BMP2. Genes downregulated by Menaquinone-7 administration included biglycan and butyrophilin [3]. Menaquinone-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats [4]. Menaquinone-7 (10 µM) promotes osteoblast maturation thereby increasing osteogenic differentiation [5].
Menaquinone-7 increased The bone formation marker osteocalcin (OC), which is the bone formation marker [6]. Menaquinone-7 (200 mg/1,000 g fed with diets) supplementation decreases the bone resorption index and increases the bone formation index, balancing bone metabolism, and is considered to prevent bone loss [6].
References:
[1]. Mahdinia E, Demirci A, Berenjian A. Production and application of menaquinone-7 (vitamin K2): a new perspective[J]. World Journal of Microbiology and Biotechnology, 2017, 33(1): 1-7.
[2]. Katsuyama H, Otsuki T, Tomita M, et al. Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells[J]. International journal of molecular medicine, 2005, 15(2): 231-236.
[3]. Katsuyama H, Saijoh K, Otsuki T, et al. Menaquinone-7 regulates gene expression in osteoblastic MC3T3E1 cells[J]. International journal of molecular medicine, 2007, 19(2): 279-284.
[4]. Ehara Y, Takahashi H, Hanahisa Y, et al. Effect of vitamin K2 (menaquinone-7) on bone metabolism in the femoral-metaphyseal tissues of normal and skeletal-unloaded rats: enhancement with zinc[J]. Research in experimental medicine, 1996, 196(1): 171-178.
[5]. Akbulut A C, Wasilewski G B, Rapp N, et al. Menaquinone-7 supplementation improves osteogenesis in pluripotent stem cell derived mesenchymal stem cells[J]. Frontiers in cell and developmental biology, 2021, 8: 618760.
[6]. Brown J P, Malaval L, Chapuy M C, et al. Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis[J]. The Lancet, 1984, 323(8386): 1091-1093.
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