Home>>MeOSuc-Ala-Ala-Pro-Val-AMC
MeOSuc-Ala-Ala-Pro-Val-AMC Catalog No.GC44157

A fluorogenic substrate for certain elastases

Size Price Stock Qty
1mg
$33.00
In stock
5mg
$98.00
In stock
10mg
$179.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 72252-90-5 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES COC(CCC(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)=O)C)=O)C)=O)=O
Formula C31H41N5O9 M.Wt 627.7
Solubility DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 16 mg/ml Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase. This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.