Metipranolol (hydrochloride) (Synonyms: Trimepranol) |
| Catalog No.GC44185 |
Metipranolol is a non-selective β-adrenergic receptor (β-AR) antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36592-77-5
Sample solution is provided at 25 µL, 10mM.
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Metipranolol is a non-selective β-adrenergic receptor (β-AR) antagonist. It binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM) and inhibits relaxation induced by isoproterenol in guinea pig atrium and by fenoterol in rat uterus (pA2s = 8.3 and 8.4, respectively). In vitro, metipranolol (100 μM) inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates. In vivo, topical ocular application of metipranolol (0.3%) decreases α-chymotrypsin-induced increases in intraocular pressure (IOP) in rabbits. It also inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
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