Mildronate (hydrate) (Synonyms: Meldonium, MET88, Quaterine, THP) |
| Catalog No.GC44196 |
Mildronate (hydrate) (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86426-17-7
Sample solution is provided at 25 µL, 10mM.
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Mildronate is a structural analog of γ-butyrobetaine (γBB), an intermediate in the biosynthesis of carnitine. It blocks carnitine synthesis by inhibiting γBB hydroxylase (IC50 = 62 µM) and, less potently, carnitine acetyltransferase (Ki = 1.6 mM). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer's disease.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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