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Mirtazapine (Synonyms: 6-Azamianserin, ORG 3770)

Catalog No.GC11447

5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist

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Mirtazapine Chemical Structure

Cas No.: 85650-52-8

Size Price Stock Qty
10mM (in 1mL DMSO)
$38.00
In stock
10mg
$34.00
In stock
50mg
$67.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

References:
[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64.
[2]. Waldinger, M.D., H.H. Berendsen, and D.H. Schweitzer, Treatment of hot flushes with mirtazapine: four case reports. Maturitas, 2000. 36(3): p. 165-8.
[3]. Garcia-Sevilla, J.A., et al., Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment. Neuropsychopharmacology, 2004. 29(3): p. 580-8.

Chemical Properties

Cas No. 85650-52-8 SDF
Synonyms 6-Azamianserin, ORG 3770
Chemical Name 2-methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine
Canonical SMILES [H]C1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C3=C4N=C([H])C([H])=C3[H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H]
Formula C17H19N3 M.Wt 265.35
Solubility ≥ 11.9mg/mL in DMSO Storage Store at 2-8°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.7686 mL 18.843 mL 37.6861 mL
5 mM 0.7537 mL 3.7686 mL 7.5372 mL
10 mM 0.3769 mL 1.8843 mL 3.7686 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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