Mometasone (Synonyms: (+)-Mometasone) |
| Catalog No.GC47698 |
A synthetic glucocorticoid with anti-inflammatory and anti-allergic activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 105102-22-5
Sample solution is provided at 25 µL, 10mM.
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Mometasone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic activities.1,2,3 In vivo, mometasone (3 mg/kg) reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury.1 Intranasal administration of mometasone (0.2 µg/animal) reduces nose-rubbing behavior, sneezing, and nasal mucosal levels of IL-4 in a mouse model of allergic rhinitis.2 Mometasone also reduces nasal mucosal epithelial destruction, fibrosis, and cilia loss in a rat model of rhinitis medicamentosa induced by oxymetazoline .
1.Kitlevsen, D.K., Povlsen, G.K., Berezin, V., et al.NCAM-induced intracellular signaling revisitedJ. Neurosci. Res.86(4)727-743(2008) 2.Williams, E.J., Furness, J., Walsh, F.S., et al.Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherinNeuron.13(3)583-594(1994) 3.Van Acker, H.H., Van Acker, Z.P., Versteven, M., et al.CD56 homodimerization and participation in anti-tumor immune effector cell functioning: A role for interleukin-15Cancers (Basel)11(7)1029(2019)
| Cas No. | 105102-22-5 | SDF | |
| Synonyms | (+)-Mometasone | ||
| Canonical SMILES | Cl[C@@]12[C@](CCC([C@@]2(C=C3)C)=CC3=O)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@](C(CCl)=O)(O)[C@@H](C4)C)C | ||
| Formula | C22H28Cl2O4 | M.Wt | 427.4 |
| Solubility | Methanol: Slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3397 mL | 11.6986 mL | 23.3973 mL |
| 5 mM | 0.4679 mL | 2.3397 mL | 4.6795 mL |
| 10 mM | 0.234 mL | 1.1699 mL | 2.3397 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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