MSC 2032964A |
| Catalog No.GC50223 |
Potent and selective ASK1 inhibitor; orally bioavailable
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1124381-43-6
Sample solution is provided at 25 µL, 10mM.
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Potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.
Guo et al (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2 504 PMID:21064192
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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