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Mycophenolic Acid β-D-Glucuronide (Synonyms: MPAG,Mycophenolic Acid Glucosiduronate)

Catalog No.GC41325

Mycophenolic Acid β-D-Glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic Acid β-D-Glucuronide shows anti-tumor activity and can be used in adenocarcinoma research.

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Mycophenolic Acid β-D-Glucuronide Chemical Structure

Cas No.: 31528-44-6

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1mg
$99.00
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5mg
$315.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Mycophenolic acid β-D-glucuronide (MPAG) is the primary metabolite of the antibiotic mycophenolic acid, a potent inhibitor of inosine monophosphate dehydrogenase. Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes, thus preventing lymphocyte proliferation and activation. Mycophenolic acid, typically used in clinical settings as a chemotherapeutic or immunosuppressant agent, is rapidly conjugated on adsorption and circulates mostly in the form of its glucuronide conjugate. At 6 mg/mouse/day, MPAG has been reported to show significant antitumor activity against Ehrlich solid tumors. This glucuronide is typically used as an internal standard for therapeutic drug monitoring analyses of serum or whole blood by HPLC or LC-MS to confirm that patients remain within the drug’s therapeutic range.

Chemical Properties

Cas No. 31528-44-6 SDF
Synonyms MPAG,Mycophenolic Acid Glucosiduronate
Chemical Name 5-[(2E)-5-carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl β-D-glucopyranosiduronic acid
Canonical SMILES O=C1OCC2=C(C)C(OC)=C(C/C=C(C)/CCC(O)=O)C(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=C21
Formula C23H28O12 M.Wt 496.5
Solubility 10mg/mL in DMSO; 5mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0141 mL 10.0705 mL 20.141 mL
5 mM 0.4028 mL 2.0141 mL 4.0282 mL
10 mM 0.2014 mL 1.007 mL 2.0141 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 26 reference(s) in Google Scholar.)

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