N-Acetyl-4-benzoquinone imine (Synonyms: NAPQI, N-Acetyl-p-benzoquinonimine) |
| Catalog No.GC44299 |
N-Acetyl-4-benzoquinone imine is the toxic metabolite of Acetaminophen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 50700-49-7
Sample solution is provided at 25 µL, 10mM.
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N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
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