N-Arachidonoyl Dopamine (Synonyms: NADA) |
| Catalog No.GC18506 |
N-Arachidonoyl Dopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM.
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Cas No.: 199875-69-9
Sample solution is provided at 25 µL, 10mM.
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Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA). NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 uM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.
Review for N-Arachidonoyl Dopamine
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
Review for N-Arachidonoyl Dopamine
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