N-desmethyl Sertraline (hydrochloride) (Synonyms: N-desmethyl Sertraline) |
| Catalog No.GC49583 |
A metabolite of sertraline
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Cas No.: 675126-09-7
Sample solution is provided at 25 µL, 10mM.
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N-desmethyl Sertraline is a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline .1 It is formed from sertraline primarily by the cytochrome P450 (CYP) isoform CYP2B6 and to a lesser extent by CYP2C19, -2C9, -2D6, and -3A in human liver microsomes. N-desmethyl Sertraline has been found in wastewater effluent.2
1.Obach, R.S., Cox, L.M., and Tremaine, L.M.Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: An in vitro studyDrug Metab. Dispos.33(2)262-270(2005) 2.Lajeunesse, A., Gagnon, C., and SauvÉ, S.Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometryAnal. Chem.80(14)5325-5333(2008)
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