N-Desmethyltamoxifen |
| Catalog No.GC25662 |
N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
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Cas No.: 31750-48-8
Sample solution is provided at 25 µL, 10mM.
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N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
[1] Vertosick FT Jr, et al. J Neurooncol. 1994;19(2):97-103. [2] Morad SA, et al. Biochim Biophys Acta. 2015 Jul;1851(7):919-28.
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