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N-(p-amylcinnamoyl) Anthranilic Acid (Synonyms: ACA)

Catalog No.GC13930

phospholipase A2 (PLA2) inhibitor and TRP channel blocker

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N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure

Cas No.: 110683-10-8

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10mM (in 1mL DMSO)
$60.00
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25mg
$55.00
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50mg
$87.00
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100mg
$151.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad-spectrum phospholipase A2 (PLA2) inhibitor and TRP channel blocker [1] [2].

PLA2 enzymes are a family of structurally different enzymes including at least nine subfamilies. The mammalian TRP proteins including at least 27 members and can be grouped into TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML six subfamilies [1].

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad-spectrum PLA2 inhibitor and TRP channel blocker [1] [2]. In HEK293 cells transfected with human TRPM2, ACA (20 ?M) completely blocked H2O2-induced Ca2+ signals and ADPR-induced whole-cell currents with IC50 value of 1.7 ?M. ACA (20 ?M) also blocked human TRPM8-induced Ca2+ signals and TRPC6-mediated currents with IC50 values of 3.9 ?M and 2.3 ?M, respectively. ACA can serve as a useful tool for studying the function of TRPM2 in native cells [2]. In isolated pig cardiac ventricular myocytes, ACA reversibly inhibited ICl(Ca) with IC50 value of 4.2 ?M in a concentration-dependent way. ACA (50 ?M) also inhibited the cAMP-activated chloride current.

References:
[1].Harteneck C, Frenzel H, Kraft R.  N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75.
[2].Kraft R, Grimm C, Frenzel H, et al.  Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
[3].Gwanyanya A, Macianskiene R, Bito V, et al.  Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.

Chemical Properties

Cas No. 110683-10-8 SDF
Synonyms ACA
Chemical Name 2-((Z)-((E)-1-hydroxy-3-(4-pentylphenyl)allylidene)amino)benzoic acid
Canonical SMILES CCCCCC1=CC=C(/C([H])=C([H])/C(O)=N/C2=CC=CC=C2C(O)=O)C=C1
Formula C21H23NO3 M.Wt 337.41
Solubility ≥ 33.7mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9638 mL 14.8188 mL 29.6375 mL
5 mM 0.5928 mL 2.9638 mL 5.9275 mL
10 mM 0.2964 mL 1.4819 mL 2.9638 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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