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Naspm trihydrochloride (Synonyms: 1-Naphthylacetyl spermine)

Catalog No.GC13349

Ca2+-permeable AMPA receptor antagonist

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Naspm trihydrochloride Chemical Structure

Cas No.: 1049731-36-3

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10mg
$126.00
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Sample solution is provided at 25 µL, 10mM.

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Background

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

References:
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

Chemical Properties

Cas No. 1049731-36-3 SDF
Synonyms 1-Naphthylacetyl spermine
Chemical Name N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
Canonical SMILES O=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl
Formula C22H34N4O.3HCl M.Wt 479.91
Solubility DMSO: 1.7 mg/mL,PBS (pH 7.2): 10 mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0837 mL 10.4186 mL 20.8372 mL
5 mM 0.4167 mL 2.0837 mL 4.1674 mL
10 mM 0.2084 mL 1.0419 mL 2.0837 mL
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