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NGI-1 (ML414) Catalog No.GC33055

Size Price Stock Qty
10mM*1mLinDMSO
$111.00
In stock
5mg
$101.00
In stock
10mg
$147.00
In stock
50mg
$450.00
In stock
100mg
$818.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 790702-57-7 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(NC1=NC=C(C)S1)C2=CC(S(=O)(N(C)C)=O)=CC=C2N3CCCC3
Formula C17H22N4O3S2 M.Wt 394.51
Solubility DMSO : 160 mg/mL (405.57 mM; Need ultrasonic) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

NGI-1 is a cell permeable inhibitor.

NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In controls EGFR is biotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR is predominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization[1].

[1]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.