NMS-P715 analog |
| Catalog No.GC19265 |
NMS-P715 analog is an inhibitor of MPS1, with an IC50 of 84 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1202055-34-2
Sample solution is provided at 25 µL, 10mM.
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NMS-P715 analog is an inhibitor of MPS1, with an IC50 of 84 nM.
NMS-P715 analog (Compound 14) is an inhibitor of MPS1, with an IC50 of 84 nM; also less active on Aur-A, CDK2/A and PLK1 (IC50, 1.45, >10, 0.237 uM). In addition, NMS-P715 analog shows inhibitory effect on human tumor cell line (A2780) with an IC50 of 150 nM.
References:
[1]. Caldarelli M, et al. Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4507-11.
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