NVS-PI3-4 |
| Catalog No.GC62141 |
NVS-PI3-4 is a specific PI3Kγ inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 941580-60-5
Sample solution is provided at 25 µL, 10mM.
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NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].
NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2].
[1]. Bruce I, et al. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett. 2012;22(17):5445-5450.
[2]. Collmann E, et al. Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells’ route to allergy. J Allergy Clin Immunol. 2013;132(4):959-968.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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