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Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt) (Synonyms: Hypocretin 1, OXA)

Catalog No.GC52507

A hypothalamic neuropeptide

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Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt) Chemical Structure

Size Price Stock Qty
500 μg
$393.00
In stock
1 mg
$666.00
In stock
5 mg
$3,129.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Orexin A is a 33 amino acid hypothalamic neuropeptide with a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds.1 Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety.2 It activates the orexin-1 and -2 receptors with equal affinity (EC50s = 0.09 and 0.06 μM, respectively).3

1.Rodgers, R.J., Ishii, Y., Halford, J.C.G., et al.Orexins and appetite regulationNeuropeptides36(5)303-325(2002) 2.Schwartz, M.W.Orexins and appetite: The big picture of energy homeostasis gets a little biggerNat. Med.4385-386(1998) 3.Lang, M., SÖll, R.M., DÜrrenberger, F., et al.Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligandsJ. Med. Chem.47(5)1153-1160(2004)

Chemical Properties

Cas No. SDF Download SDF
Synonyms Hypocretin 1, OXA
Canonical SMILES NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@@]([H])(NC(CNC([C@H](C)NC([C@H](C)NC([C@H](CC1=CN=CN1)NC([C@@H](NC(CNC([C@H](C)NC(CNC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@@H]4N5)NC([C@@H](NC([C@H](CSSC[C@@H](C5=O)NC([C@H](CC(O)=O)NC([C@@H]6CCCN6C([C@@H](NC([C@@H]7CCCN7C(C8NC(CC8)=O)=O)=O)CC(C)C)=O)=O)=O)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC4=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)[C@H](O)C)=O)=O)CO)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)=O)=O)=O)[C@@H](C)CC)=O)CC(C)C)=O)[C@H](O)C)=O)CC(C)C)=O.OC(C(F)(F)F)=O
Formula C152H243N47O44S4 ? XCF3COOH M.Wt 3561.1
Solubility DMSO: 3 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.2808 mL 1.4041 mL 2.8081 mL
5 mM 0.0562 mL 0.2808 mL 0.5616 mL
10 mM 0.0281 mL 0.1404 mL 0.2808 mL
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