Oxyphenbutazone (Synonyms: G 27202, p-Hydroxyphenylbutazone, NSC 526053, Ro 04-4410) |
| Catalog No.GC40651 |
Oxyphenbutazone is a metabolite of phenylbutazone.
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Cas No.: 129-20-4
Sample solution is provided at 25 µL, 10mM.
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Oxyphenbutazone is a metabolite of phenylbutazone . Both compounds were identified as having anti-inflammatory effects in early studies, and, as a result, are considered NSAIDs. Interestingly, the effects of the two compounds in animal models differ, with phenylbutazone having anti-inflammatory effects in rheumatic diseases and oxyphenbutazone reducing edema in certain types of acute inflammation. Oxyphenbutazone is a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits organic anion transporter 1 (Ki = 32 µM). It inhibits the growth of MH60/BSF-2 cells induced by IL-6 (IC50 = 7.5 µM). Oxyphenbutazone stimulates neurite outgrowth at 1.5 µM and sensitizes M. tuberculosis to antimicrobials.
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