p,p'-DDD (Synonyms: 4,4'-DDD, 4,4'-Dichlorodiphenyldichloroethane, p,p-Dichlorodiphenyldichloroethane, NSC 8941) |
| Catalog No.GC41249 |
p,p'-DDD is a metabolite of the organochlorine pesticide DDT.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72-54-8
Sample solution is provided at 25 µL, 10mM.
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p,p'-DDD is a metabolite of the organochlorine pesticide DDT. It is an agonist at estrogen receptor α (ERα) and ERβ, increasing transactivation with 20% relative effective concentrations (REC20) of 3.2 and 2.4 µM, respectively, in CHO-K1 cells expressing the human receptors. It inhibits DHT-induced androgen receptor transcription with a 20% relative inhibitory concentration (RIC20) of 0.71 µM. p,p'-DDD increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 100 and 150 µg/ml. Blood levels of p,p'-DDD and the level of PBMC apoptosis are increased in children exposed to DDT compared with unexposed children. It is not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg).
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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