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PARPi-FL

Catalog No.GC50459

Potent fluorescent PARP inhibitor; cell permeable

Products are for research use only. Not for human use. We do not sell to patients.

PARPi-FL Chemical Structure

Cas No.: 1380359-84-1

Size Price Stock Qty
1 mg
$324.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE . Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.

Thurber et al (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat.Commun. 4 1504 PMID:23422672 |Thurber et al (2014) Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. Mol.Cancer Ther. 13 986 PMID:24552776 |Dubach et al (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat.Chem.Biol. 13 168 PMID:27918558

Chemical Properties

Cas No. 1380359-84-1 SDF
Canonical SMILES CC1=CC(C)=[N+]2C1=CC3=CC=C(N3[B-]2(F)F)CCC(N4CCN(C(C5=CC(CC6=NNC(C7=CC=CC=C67)=O)=CC=C5F)=O)CC4)=O
Formula C34H32BF3N6O3 M.Wt 640.46
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.5614 mL 7.8069 mL 15.6138 mL
5 mM 0.3123 mL 1.5614 mL 3.1228 mL
10 mM 0.1561 mL 0.7807 mL 1.5614 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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