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PD 168568 (hydrochloride)

Catalog No.GC49667

A dopamine D4 receptor antagonist

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PD 168568 (hydrochloride) Chemical Structure

Cas No.: 1782532-06-2

Size Price Stock Qty
1 mg
$46.00
In stock
5 mg
$149.00
In stock
10 mg
$230.00
In stock
25 mg
$517.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

PD 168568 is a dopamine D4 receptor antagonist (Ki = 8.8 nM).1 It is selective for dopamine D4 over D2 receptors (Ki = 1,842 nM). PD 168568 (3 mg/kg) reverses amphetamine-induced hyperlocomotion in rats. It also inhibits the growth of glioblastoma neural stem cells when used at concentrations of 25 and 50 µM.2

1.Belliotti, T.R., Brink, W.A., Kesten, S.R., et al.Isoindolinone enantiomers having affinity for the dopamine D4 receptorBioorg. Med. Chem. Lett.8(12)1499-1502(1998) 2.Dolma, S., Selvadurai, H.J., Lan, X., et al.Inhibition of dopamine receptor D4 impedes autophagic flux, proliferation, and survival of glioblastoma stem cellsCancer Cell29(6)859-873(2016)

Chemical Properties

Cas No. 1782532-06-2 SDF Download SDF
Canonical SMILES O=C1NC(CCN2CCN(CC2)C3=CC(C)=C(C)C=C3)C4=CC=CC=C14.Cl.Cl
Formula C22H27N3O • 2HCl M.Wt 422.4
Solubility DMSO: 100 mM,Water: 50 mM Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3674 mL 11.8371 mL 23.6742 mL
5 mM 0.4735 mL 2.3674 mL 4.7348 mL
10 mM 0.2367 mL 1.1837 mL 2.3674 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Reviews

Review for PD 168568 (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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