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(+)-Penbutolol ((R)-Penbutolol) Catalog No.GC31597

Size Price Stock Qty
10mM*1mLinDMSO
$151.00
In stock
5mg
$138.00
In stock
10mg
$220.00
In stock
50mg
$689.00
In stock
100mg
$1,103.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 38363-41-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O[C@@H](COC1=C(C=CC=C1)C2CCCC2)CNC(C)(C)C
Formula C18H29NO2 M.Wt 291.43
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].

(+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1].(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2].

[1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8.