Peptide YY (3-36) (trifluoroacetate salt) (Synonyms: Pancreatic Peptide YY, Peptide Tyrosine Tyrosine)

Name: Peptide YY (3-36) (trifluoroacetate salt)
Brand: GlpBio
SKU: GC52502
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC52502

A satiety hormone

Products are for research use only. Not for human use. We do not sell to patients.

Peptide YY (3-36) (trifluoroacetate salt) Chemical Structure

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500 μg	$276.00	In stock
1 mg	$524.00	In stock

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

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618, 1017–1023 (2023)

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183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

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21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >95.00%

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.¹ PYY, along with neuropeptide Y , inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.^1,2 Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC₅₀ = 11.4 nM in human colon mucosa).³ PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.²

1.Holzer, P., Reichmann, F., and Farzi, A.Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axisNeuropeptides46(6)261-274(2012) 2.le Roux, C.W., and Bloom, S.R.Peptide YY, appetite and food intakeProc. Nutr. Soc.64(2)213-216(2005) 3.Cox, H.M., and Tough, I.R.Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosaBr. J. Pharmacol.135(6)1505-1512(2002)

Cas No.		SDF	Download SDF
Synonyms	Pancreatic Peptide YY, Peptide Tyrosine Tyrosine
Canonical SMILES	NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(CNC([C@@H]2CCCN2C([C@@H](NC([C@H](CCC(O)=O)NC([C@@H]3CCCN3C([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])N[H])=O)=O)=O)=O)C)=O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)CC5=CC=C(O)C=C5)=O)C)=O)=O)=O)=O)CC6=CN=CN6)=O)CC7=CC=C(O)C=C7)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O.OC(C(F)(F)F)=O
Formula	C180H279N53O54 ? XCF3COOH	M.Wt	4049.5
Solubility	DMSO: soluble,Water: 1 mg/ml	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.2469 mL	1.2347 mL	2.4694 mL
	5 mM	0.0494 mL	0.2469 mL	0.4939 mL
	10 mM	0.0247 mL	0.1235 mL	0.2469 mL

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Peptide YY (3-36) (trifluoroacetate salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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Peptide YY (3-36) (trifluoroacetate salt) (Synonyms: Pancreatic Peptide YY, Peptide Tyrosine Tyrosine)

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