PF 04449913 maleate |
| Catalog No.GC50491 |
Potent Smo antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2030410-25-2
Sample solution is provided at 25 µL, 10mM.
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Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
Munchhof et al (2011) Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med.Chem.Lett. 3 106 PMID:24900436 |Fukushima et al (2016) Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107 1422 PMID:27461445 |Giordani et al (2016) The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells. Oncotarget 7 55313 PMID:27486815
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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