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PF 04479745

Catalog No.GC50668

PF 04479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM). PF 04479745 can be used in the research of cardiovascular disease like hypertension.

Products are for research use only. Not for human use. We do not sell to patients.

PF 04479745 Chemical Structure

Cas No.: 1065110-43-1

Size Price Stock Qty
1mg
$179.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Potent and selective 5-HT2C agonist (EC50 = 10 nM). Exhibits > 100-fold selectivity over a panel of 90 receptors, enzymes and ion channels, except for 5-HT2A (IC50 = 360 nM antagonist), 5-HT2B (EC50 = 67 nM antagonist), 5-HT1A and 5-HT6 (functional activity not tested).

Chemical Properties

Cas No. 1065110-43-1 SDF
Canonical SMILES C[C@@H]1C2=NC(CC3=CC=CC=C3)=NC(NC)=C2CCNC1
Formula C17H22N4 M.Wt 282.39
Solubility DMSO|28.24|100|ethanol|28.24|100| Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.5412 mL 17.706 mL 35.412 mL
5 mM 0.7082 mL 3.5412 mL 7.0824 mL
10 mM 0.3541 mL 1.7706 mL 3.5412 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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