Home>>PF-05274857 (hydrochloride)
PF-05274857 (hydrochloride) Catalog No.GC18599

Size Price Stock Qty
1mg
$31.00
In stock
5mg
$100.00
In stock
10mg
$185.00
In stock
25mg
$387.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 1613439-62-5 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES ClC1=C(C2=NC=C(C)C=C2C)C=C(N3CCN(C(CCS(C)(=O)=O)=O)CC3)N=C1.Cl
Formula C20H25ClN4O3S.HCl M.Wt 473.4
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Sonic hedgehog (Shh) signaling is initiated by binding of the ligand, Shh, to the receptor Patched 1, which relieves suppression by the associated receptor Smoothened (Smo). PF-05274857 is an antagonist which binds Smo (Ki = 4.6 nM), blocking Gli1 transcription in cells stimulated with Shh (IC50 = 2.7 nM). When administered orally, it distributes through plasma to skin and tumor and remains metabolically stable. PF-05274857 also penetrates the blood-brain barrier and inhibits Smo activity in the brain.