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PF 3084014 hydrobromide (Synonyms: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide)

Catalog No.GC50251

PF 3084014 hydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by PF 3084014 hydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.

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PF 3084014 hydrobromide Chemical Structure

Cas No.: 1962925-29-6

Size Price Stock Qty
10 mg
$249.00
In stock
50 mg
$1,053.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853

Chemical Properties

Cas No. 1962925-29-6 SDF
Synonyms PF-3084014 dihydrobromide; PF-03084014 dihydrobromide
Canonical SMILES O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br
Formula C27H41F2N5O.2HBr M.Wt 651.47
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.535 mL 7.675 mL 15.3499 mL
5 mM 0.307 mL 1.535 mL 3.07 mL
10 mM 0.1535 mL 0.7675 mL 1.535 mL
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Review for PF 3084014 hydrobromide

Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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