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Phenformin-d5 (hydrochloride) (Synonyms: Phenethylbiguanide-d5 hydrochloride)

Catalog No.GC49530

An internal standard for the quantification of phenformin

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Phenformin-d5 (hydrochloride) Chemical Structure

Cas No.: N/A

Size Price Stock Qty
500 µg
$63.00
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1 mg
$111.00
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5 mg
$495.00
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10 mg
$865.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Phenformin-d5 is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.1 It reduces blood glucose levels in a mouse model of diabetes induced by alloxan when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.2 It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.3 Formulations containing phenformin were previously used in the treatment of diabetes mellitus.

1.Li, W.-L., Wu, J.-L., Ren, B.-R., et al.Pharmacological studies on anti-hyperglycemic effect of folium eriobotryaeAm. J. Chin. Med.35(4)705-711(2007) 2.Arieff, A.I., Park, R., Leach, W.J., et al.Pathophysiology of experimental lactic acidosis in dogsAm. J. Physiol.239(2)F135-F142(1980) 3.Appleyard, M.V.C.L., Murray, K.E., Coates, P.J., et al.Phenformin as prophylaxis and therapy in breast cancer xenograftsBr. J. Cancer106(6)1117-1122(2012)

Chemical Properties

Cas No. N/A SDF Download SDF
Synonyms Phenethylbiguanide-d5 hydrochloride
Canonical SMILES N=C(NC(NCCC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=N)N.Cl
Formula C10H10D5N5 • HCl M.Wt 246.8
Solubility DMF: 33 mg/mL,DMSO: 33 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 5mg/mL Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.0519 mL 20.2593 mL 40.5186 mL
5 mM 0.8104 mL 4.0519 mL 8.1037 mL
10 mM 0.4052 mL 2.0259 mL 4.0519 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 36 reference(s) in Google Scholar.)

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